Article
In vivo mutagenesis induced by benzo[a]pyrene instilled into the lung of gpt delta transgenic mice.
Environmental and molecular mutagenesis - 1 May 2005
Hashimoto Akiko H, Amanuma Kimiko, Hiyoshi Kyoko, Takano Hirohisa, Masumura Ken-Ichi, Nohmi Takehiko, Aoki Yasunobu
Abstract excerpt
Benzo[a]pyrene (B[a]P) is a ubiquitous airborne pollutant whose mutagenicity has been evaluated previously by oral and intraperitoneal administration to experimental animals. In this study, mutagenesis in the lungs, the target organ of air pollutants, was examined after a single intratracheal instillation of 0-2 mg B[a]P into gpt delta transgenic mice. Intratracheal injection of B[a]P resulted in a statistically...
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