Article
Mechanistic relationships between DNA adducts, oncogene mutations, and lung tumorigenesis in strain A mice.
Experimental lung research - 1 Jan 2000
Nesnow S, Ross J A, Mass M J, Stoner G D
Abstract excerpt
This paper describes a series of studies on the lung tumorigenic activities of polycyclic aromatic hydrocarbons (PAHs) in strain A/J mice, their ability to form PAH-DNA adducts in lung tissues, and their ability to mutate the Ki-ras oncogene in PAH-induced tumors. Seven PAHs were studied: cyclope...
Topics
- Adenoma
- Animals
- Carcinogens
- DNA Adducts
- DNA Mutational Analysis
- DNA Primers
- DNA, Neoplasm
- Dose-Response Relationship, Drug
- Genes, ras
- Lung Neoplasms
- Male
- Mice
- Mice, Inbred A
- Mutation
- Polycyclic Aromatic Hydrocarbons
- Polymerase Chain Reaction