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Article

Mechanistic relationships between DNA adducts, oncogene mutations, and lung tumorigenesis in strain A mice.

Experimental lung research - 1 Jan 2000

Nesnow S, Ross J A, Mass M J, Stoner G D

Abstract excerpt

This paper describes a series of studies on the lung tumorigenic activities of polycyclic aromatic hydrocarbons (PAHs) in strain A/J mice, their ability to form PAH-DNA adducts in lung tissues, and their ability to mutate the Ki-ras oncogene in PAH-induced tumors. Seven PAHs were studied: cyclopenta[cd]pyrene (CPP), benzo[a]pyrene (B[a]P), benzo[b]fluoranthene (B[b]F), dibenz[a,h] anthracene (DBA),...

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Identifiers

PMID: 9659573
DOI: 10.3109/01902149809087376

Genes

PAH

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