Article
p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.
Cancer research - 1 Aug 1991
Lehman T A, Bennett W P, Metcalf R A, Welsh J A, Ecker J, Modali R V, Ullrich S, Romano J W, Appella E, Testa J R
Abstract excerpt
The p53 tumor suppressor gene is frequently mutated and the K-ras oncogene is occasionally mutated in primary specimens of human lung carcinomas. These mutated genes also cooperate in the immortalization and neoplastic transformation of rodent cells. To determine whether these mutations are necessary for maintenance of the immortalized and/or neoplastically transformed states of human bronchial epithelial cells,...
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