Article
TP53 codon 72 and intron 3 polymorphisms and mutational status in gastric cancer: an association with tumor onset and prognosis.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2012
Neves Filho Eduardo Henrique Cunha, Cordeiro Denise Ellen Francelino, Vieira Ana Patrícia Freitas, Rabenhorst Silvia Helena Barem
Abstract excerpt
Although TP53 alterations have been studied in human tumors, data considering the role of two common TP53 polymorphisms (Pro72Arg in codon 72 and Ins16bp in intron 3) and their associations with TP53 mutations in gastric cancer are very limited. Thus, we analyzed these parameters taking into consideration the clinicopathological data. DNA from 106 gastric tumor samples was available for TP53 Pro72Arg and TP53...
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