Article
P53 mutations in gastric carcinomas.
British journal of cancer - 1 May 1992
Seruca R, David L, Holm R, Nesland J M, Fangan B M, Castedo S, Sobrinho-Simões M, Børresen A L
Abstract excerpt
We carried out an immunohistochemical study and DNA analysis of 30 gastric carcinomas to evaluate p53 overexpression and allelic loss at 17p. The immunohistochemical study demonstrated immunoreactivity for p53 protein in four cases. Allelic loss for the pYNZ22.1 marker was detected in nine cases. In total, ten cases showed immunoreactivity for p53 protein, allelic loss, or both. The study of nine of these cases...
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