P53 mutations in gastric carcinomas.

doi:10.1038/bjc.1992.149

Back to search

Article

P53 mutations in gastric carcinomas.

British journal of cancer - 1 May 1992

Seruca R, David L, Holm R, Nesland J M, Fangan B M, Castedo S, Sobrinho-Simões M, Børresen A L

Abstract excerpt

We carried out an immunohistochemical study and DNA analysis of 30 gastric carcinomas to evaluate p53 overexpression and allelic loss at 17p. The immunohistochemical study demonstrated immunoreactivity for p53 protein in four cases. Allelic loss for the pYNZ22.1 marker was detected in nine cases....

Topics

Alleles
DNA, Neoplasm
Genes, p53
Humans
Immunohistochemistry
Mutation
Stomach Neoplasms
Tumor Suppressor Protein p53

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.