Article
[Mutations of the p53 suppressor gene in gastric adenocarcinoma].
Revista medica de Chile - 1 May 1998
Aranda M, Náquira N, Karque R, Mendoza H, Sepúlveda C, Silva C
Abstract excerpt
BACKGROUND: We have shown numeric alterations such as hyperploidy and hypoploidy with loss of chromosome 17 in primary gastric cancer. This chromosome maps p53 suppressor gene that induces the transcription of genes related to cellular cycle control, DNA synthesis and repair, cellular differentiation and apoptosis. AIM: To analyze, at a molecular level, the possible alterations of p53 suppressor gene in samples...
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