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Article

Infrequent somatic mutations of the p73 gene in various human cancers.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Apr 1999

Han S, Semba S, Abe T, Makino N, Furukawa T, Fukushige S, Takahashi H, Sakurada A, Sato M, Shiiba K, Matsuno S, Nimura Y, Nakagawara A, Horii A

Abstract excerpt

AIMS: It has already been reported that loss of heterozygosity (LOH) on chromosome 1p is frequent in a variety of human cancers. This finding implies the presence of some important tumour suppressor genes in this region. p73, a candidate tumour suppressor gene identified recently in chromosome band 1p36.33, encodes a protein highly homologous to p53. To investigate the role of the p73 gene in human...

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Share to Chromosomes, Human, Pair 1
Share to Digestive System Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Mutation, Missense

Share to Neuroblastoma

Share to Polymorphism, Single-Stranded Conformational

Share to Tumor Protein p73

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Source

Identifiers

PMID: 10218465
DOI: 10.1053/ejso.1998.0626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Infrequent somatic mutations of the p73 gene in various human cancers.PMID 10218465Read ↗

p73 mutations are not detected in sporadic and hereditary breast cancer.Semantic proximity Read ↗

Mutational analysis of the p73 gene in human breast cancers.Semantic proximity Read ↗

Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53.Semantic proximity Read ↗

Frequent allelic losses on the short arm of chromosome 1 and decreased expression of the p73 gene at 1p36.3 in squamous cell carcinoma of the oral cavity.Semantic proximity Read ↗

Frequent inactivation of the <i>p73</i> gene by abnormal methylation or LOH in non‐Hodgkin's lymphomasSemantic proximity Read ↗

p73, a gene related to p53, is not mutated in esophageal carcinomas.Semantic proximity Read ↗

Loss of heterozygosity, allele silencing and decreased expression of p73 gene in breast cancers: prevalence of alterations in inflammatory breast cancers.Semantic proximity Read ↗

Mutational analysis of the p73 gene localized at chromosome 1p36.3 in colorectal carcinomas.Semantic proximity Read ↗

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Allelic loss at the p73 locus (1p36.33) is infrequent in malignant melanoma.Semantic proximity Read ↗

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