Article
Genetic status of p53 in stomach cancer: somatic mutations and polymorphism of codon 72.
Bulletin of experimental biology and medicine - 1 Feb 2006
Belyavskaya V A, Vardosanidze V K, Smirnova O Yu, Karakin E I, Savkin I V, Gervas P A, Cherdyntseva N V, Voevoda M I
Abstract excerpt
The incidence of somatic mutagenesis of p53 oncosuppressor protein in malignant tumors of the stomach and genetic polymorphism of p53 were studied in patients with stomach cancer on DNA samples isolated from tumor tissues obtained during surgery. The incidence of Pro/Pro genotype increased in the patients, while the percentage of Arg/Pro heterozygotes was markedly lower compared to long-living persons without...
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