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Article

Regulation of VH gene repertoire and somatic mutation in germinal centre B cells by passively administered antibody.

Immunology - 1 Oct 1999

Song H, Nie X, Basu S, Singh M, Cerny J

Abstract excerpt

Immunization with T-dependent antigens induces a rapid differentiation of B cells to plasmacytes that produce the primary immunoglobulin M (IgM) and IgG antibodies with low affinities for the immunogen. It is proposed that the IgG antibody forms immune complexes with the residual antigen which provide an important stimulus for the formation of germinal centres (GC) and the activation of somatic mutation. This...

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Identifiers

PMID: 10540225
DOI: 10.1046/j.1365-2567.1999.00874.x
PMCID: PMC2326929

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Source receipt: pubmed, retrieved 7 Sept 2026.

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