Article
Mutations of hepatitis B virus liver disease.
Gastroenterologia Japonica - 1 Mar 1993
Ehata T, Chuang W L, Omata M
Abstract excerpt
Individuals with chronic hepatitis B virus (HBV) infection are generally divided into asymptomatic healthy carriers and patients with chronic liver disease. Several studies have suggested that the core antigen (HBcAg) could be an immunological target of cytotoxic T lymphocytes (CTL). To investigate the possible pressure site from CTL, the entire core region of HBV DNA was sequenced in 30 subjects (10 asymptomatic...
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