Article
Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection.
The Journal of clinical investigation - 1 Jan 1992
Ehata T, Omata M, Yokosuka O, Hosoda K, Ohto M
Abstract excerpt
Individuals with chronic hepatitis B virus (HBV) infection are generally divided into asymptomatic healthy carriers and patients with chronic liver disease. Several studies have suggested that the hepatitis B core antigen could be an immunological target of cytotoxic T lymphocytes (CTL). To inves...
Topics
- Adult
- Alanine Transaminase
- Amino Acid Sequence
- Hepatitis B
- Hepatitis B Core Antigens
- Hepatitis, Chronic
- Humans
- Liver Cirrhosis
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Selection, Genetic
- Sequence Homology, Nucleic Acid
- T-Lymphocytes, Cytotoxic