Article
Precore mutations and core clustering mutations in chronic hepatitis B virus infection.
Gastroenterology - 1 Jan 1993
Chuang W L, Omata M, Ehata T, Yokosuka O, Ito Y, Imazeki F, Lu S N, Chang W Y, Ohto M
Abstract excerpt
BACKGROUND: Mutant hepatitis B virus is often associated with severe liver damage. The purpose of this study is to elucidate the relationship between mutations in hepatitis B precore/core gene and the severity of liver damage. METHODS: The hepatitis B precore/core gene from 20 patients with chronic hepatitis B virus infection was studied by polymerase chain reaction and direct sequencing. RESULTS: Missense...
Topics
- Adult
- Amino Acid Sequence
- Base Sequence
- Chronic Disease
- Female
- Hepatitis B
- Humans
- Male
- Middle Aged
- Molecular Probes
- Molecular Sequence Data
- Multigene Family
- Mutation
- Viral Core Proteins