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Article

Precore mutations and core clustering mutations in chronic hepatitis B virus infection.

Gastroenterology - 1 Jan 1993

Chuang W L, Omata M, Ehata T, Yokosuka O, Ito Y, Imazeki F, Lu S N, Chang W Y, Ohto M

Abstract excerpt

BACKGROUND: Mutant hepatitis B virus is often associated with severe liver damage. The purpose of this study is to elucidate the relationship between mutations in hepatitis B precore/core gene and the severity of liver damage. METHODS: The hepatitis B precore/core gene from 20 patients with chronic hepatitis B virus infection was studied by polymerase chain reaction and direct sequencing. RESULTS: Missense...

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PMID: 8419250
DOI: 10.1016/0016-5085(93)90861-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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