Article
Mutations in the core promoter region of hepatitis B virus in patients with chronic hepatitis B.
Journal of medical virology - 1 Jun 1996
Kurosaki M, Enomoto N, Asahina Y, Sakuma I, Ikeda T, Tozuka S, Izumi N, Marumo F, Sato C
Abstract excerpt
The core promoter region of hepatitis B virus genomes regulates transcription of the precore and pregenomic mRNAs encoding hepatitis B e antigen (HBeAg) and core antigen that contain target epitopes for cytotoxic T lymphocytes. The prevalence and clinical significance of mutations in this region...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Base Sequence
- Child
- Chronic Disease
- Female
- Genes, Viral
- Hepatitis B
- Hepatitis B virus
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Trans-Activators
- Viral Regulatory and Accessory Proteins