Article
Mutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis.
The Journal of clinical investigation - 1 Mar 1993
Ehata T, Omata M, Chuang W L, Yokosuka O, Ito Y, Hosoda K, Ohto M
Abstract excerpt
Infection with hepatitis B virus leads to a wide spectrum of liver injury, including self-limited acute hepatitis, fulminant hepatitis, and chronic hepatitis with progression to cirrhosis or acute exacerbation to liver failure, as well as an asymptomatic chronic carrier state. Several studies hav...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Base Sequence
- Child
- Codon
- DNA, Viral
- Female
- Hepatitis B
- Hepatitis B Core Antigens
- Hepatitis B Surface Antigens
- Hepatitis B e Antigens
- Hepatitis B virus
- Humans
- Immunoglobulin M
- Liver
- Male
- Middle Aged