Article
Mice lacking major histocompatibility complex class I and class II molecules.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1993
Grusby M J, Auchincloss H, Lee R, Johnson R S, Spencer J P, Zijlstra M, Jaenisch R, Papaioannou V E, Glimcher L H
Abstract excerpt
Mice lacking major histocompatibility complex (MHC) antigens were generated by mating beta 2-microglobulin-deficient, and therefore class I-deficient, animals with MHC class II-deficient animals. When housed under sterile conditions, the resulting MHC-deficient mice appear healthy, survive for ma...
Topics
- Animals
- CD4 Antigens
- CD8 Antigens
- Flow Cytometry
- Genes, MHC Class I
- Genes, MHC Class II
- Graft Survival
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Immunoglobulin G
- Mice
- Mice, Inbred BALB C
- Mice, Mutant Strains
- Phenotype