Article
Mice lacking major histocompatibility complex class I and class II molecules.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1993
Grusby M J, Auchincloss H, Lee R, Johnson R S, Spencer J P, Zijlstra M, Jaenisch R, Papaioannou V E, Glimcher L H
Abstract excerpt
Mice lacking major histocompatibility complex (MHC) antigens were generated by mating beta 2-microglobulin-deficient, and therefore class I-deficient, animals with MHC class II-deficient animals. When housed under sterile conditions, the resulting MHC-deficient mice appear healthy, survive for many months, and breed successfully. Phenotypically, MHC-deficient mice are depleted of CD4+ and CD8+ T cells in...
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