Article
Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1993
Geiser A G, Letterio J J, Kulkarni A B, Karlsson S, Roberts A B, Sporn M B
Abstract excerpt
The phenotype of the transforming growth factor beta 1 (TGF-beta 1) null mouse has been previously described and is characterized by inflammatory infiltrates in multiple organs leading to a wasting syndrome and death as early as 3 weeks after birth. Since this phenotype occurs in the absence of a...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- DNA Primers
- Fibroblasts
- Gene Expression Regulation
- Interferon-gamma
- Major Histocompatibility Complex
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Organ Specificity
- Phenotype