Article
Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1999
Kobayashi S, Yoshida K, Ward J M, Letterio J J, Longenecker G, Yaswen L, Mittleman B, Mozes E, Roberts A B, Karlsson S, Kulkarni A B
Abstract excerpt
TGF-beta 1 null (TGF-beta1-/-) mice die at 3-4 wk of age and show an autoimmune inflammatory phenotype associated with enhanced expression of both class I and II MHC molecules. To determine the role of MHC class I Ags in the autoimmune manifestations and the inflammation observed in TGF-beta 1-/- mice, we generated TGF-beta 1-/- mice in the genetic background of beta 2-microglobulin deficiency (beta 2M-/-)....
Topics
- Animals
- Antigen-Antibody Complex
- Autoantibodies
- CD8-Positive T-Lymphocytes
- Crosses, Genetic
- Embryonic and Fetal Development
- Flow Cytometry
- Genes, Lethal
- Genotype
- Histocompatibility Antigens Class II
- Inflammation
- Kidney
- Leukopoiesis