Article
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
The Journal of experimental medicine - 16 Dec 2013
Molnarfi Nicolas, Schulze-Topphoff Ulf, Weber Martin S, Patarroyo Juan C, Prod'homme Thomas, Varrin-Doyer Michel, Shetty Aparna, Linington Christopher, Slavin Anthony J, Hidalgo Juan, Jenne Dieter E, Wekerle Hartmut, Sobel Raymond A, Bernard Claude C A, Shlomchik Mark J, Zamvil Scott S
Abstract excerpt
Whether B cells serve as antigen-presenting cells (APCs) for activation of pathogenic T cells in the multiple sclerosis model experimental autoimmune encephalomyelitis (EAE) is unclear. To evaluate their role as APCs, we engineered mice selectively deficient in MHC II on B cells (B-MHC II(-/-)), and to distinguish this function from antibody production, we created transgenic (Tg) mice that express the myelin...
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