Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease.

Abstract excerpt

Class II major histocompatibility complex (MHC)-deficient (H-2b) mice do not express I-A or I-E molecules and, as a result, do not develop CD4 cells. Thus, they represent the ideal model for examining the importance of CD4 cells and MHC class II molecules in resistance to infection with Leishmania major and the capacity of MHC class I-restricted T cells to mediate resistance to L. major. Class II MHC-deficient...

Topics

• Animals
• CD4-Positive T-Lymphocytes
• CD8-Positive T-Lymphocytes
• Genes, MHC Class II
• Histocompatibility Antigens Class II
• Immunophenotyping
• Interferon-gamma
• Leishmania major
• Leishmaniasis, Cutaneous
• Lymph Nodes