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A mouse model of human adaptive immune functions: <i>HLA‐A2.1‐/HLA‐DR1</i>‐transgenic <i>H‐2 class I‐/class II</i>‐knockout mice

4 Oct 2004

Abstract excerpt

HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice were created and their immunological potential evaluated in response to hepatitis B DNA vaccine. Every single immunized mouse developed hepatitis B virus-specific antibodies, HLA-DR1-restricted helper, and HLA-A2.1-restricted cytolytic T cell responses directed at the same immunodominant epitopes as those identified in naturally infected or...

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Identifiers

PMID: 15468058
DOI: 10.1002/eji.200425463

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