Article
Polarized helper-T-cell responses against Leishmania major in the absence of B cells.
Infection and immunity - 1 Jan 1999
Brown D R, Reiner S L
Abstract excerpt
B-cell-to-T-cell signaling can shape helper T (Th) cell responses. During infection with Leishmania major, Th response is critical in determining the outcome of disease. Resistance depends on the generation of a protective Th1 response, while susceptibility is mediated by the generation of a Th2...
Topics
- Animals
- B-Lymphocytes
- Genetic Predisposition to Disease
- Immunity, Innate
- Leishmania major
- Leishmaniasis, Cutaneous
- Lymphopenia
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Mutant Strains
- T-Lymphocytes, Helper-Inducer