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Article

Polarized helper-T-cell responses against Leishmania major in the absence of B cells.

Infection and immunity - 1 Jan 1999

Brown D R, Reiner S L

Abstract excerpt

B-cell-to-T-cell signaling can shape helper T (Th) cell responses. During infection with Leishmania major, Th response is critical in determining the outcome of disease. Resistance depends on the generation of a protective Th1 response, while susceptibility is mediated by the generation of a Th2 response. In this study, we determined whether B cells are required for the development of polarized Th1 and Th2...

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Source

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Identifiers

PMID: 9864225
DOI: 10.1128/IAI.67.1.266-270.1999
PMCID: PMC96306

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Source receipt: pubmed, retrieved 7 Sept 2026.

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