Article
A mutant antigen-presenting cell defective in antigen presentation expresses class II MHC molecules with an altered conformation.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 1993
Dang L H, Lien L L, Benacerraf B, Rock K L
Abstract excerpt
Ag presentation by APC to class II MHC-restricted T cells involves a sequence of events: 1) intracellular processing of protein Ag into immunogenic peptides, 2) specific binding of peptides to class II MHC molecules, and then 3) transport of the MHC-peptide complexes to the plasma membrane. The c...
Topics
- Animals
- Antigen-Presenting Cells
- Antigens, Differentiation, B-Lymphocyte
- Cell Compartmentation
- Cells, Cultured
- Histocompatibility Antigens Class II
- Hybridomas
- In Vitro Techniques
- Mice
- Mice, Inbred Strains
- Mutation
- Protein Conformation
- Protein Processing, Post-Translational
- T-Lymphocytes