Article
Deletion of a C-terminal sequence of the class II-associated invariant chain abrogates invariant chains oligomer formation and class II antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1995
Bertolino P, Staschewski M, Trescol-Biémont M C, Freisewinkel I M, Schenck K, Chrétien I, Forquet F, Gerlier D, Rabourdin-Combe C, Koch N
Abstract excerpt
The MHC class II-associated invariant chain (Ii) is involved in Ag processing and presentation. Physical association of MHC class II molecules with Ii and an effect of Ii on peptide loading to class II have been demonstrated, but to date these functions have not been related to a particular regio...
Topics
- Animals
- Antigen Presentation
- Antigens, Differentiation, B-Lymphocyte
- Base Sequence
- Biopolymers
- DNA
- Egg Proteins
- Histocompatibility Antigens Class II
- L Cells
- Lymphocyte Activation
- Mice
- Molecular Sequence Data
- Mutation