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Article

Deletion of a C-terminal sequence of the class II-associated invariant chain abrogates invariant chains oligomer formation and class II antigen presentation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1995

Bertolino P, Staschewski M, Trescol-Biémont M C, Freisewinkel I M, Schenck K, Chrétien I, Forquet F, Gerlier D, Rabourdin-Combe C, Koch N

Abstract excerpt

The MHC class II-associated invariant chain (Ii) is involved in Ag processing and presentation. Physical association of MHC class II molecules with Ii and an effect of Ii on peptide loading to class II have been demonstrated, but to date these functions have not been related to a particular region of Ii. We investigated luminal deletion mutants of Ii and their role in Ag processing and presentation....

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PMID: 7751615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of a C-terminal sequence of the class II-associated invariant chain abrogates invariant chains oligomer formation and class II antigen presentation.PMID 7751615Read ↗

Mutation of the invariant chain transmembrane region inhibits II degradation, prolongs association with MHC class II, and selectively disrupts antigen presentation.Semantic proximity Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

Mutations in specific I-A(k) alpha(2) and beta(2) domain residues affect surface expression.Semantic proximity Read ↗

Association of the Invariant Chain with Major Histocompatibility Complex Class I Molecules Directs Trafficking to Endocytic CompartmentsSemantic proximity Read ↗

Expression of invariant chain can cause an allele-dependent increase in the surface expression of MHC class I molecules.Semantic proximity Read ↗

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).Semantic proximity Read ↗

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.Semantic proximity Read ↗

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.Semantic proximity Read ↗

Structural requirements for major histocompatibility complex class II invariant chain endocytosis and lysosomal targeting.Semantic proximity Read ↗

DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules.Semantic proximity Read ↗

Posttranslational regulation of I-Ed by affinity for CLIP.Semantic proximity Read ↗

Invariant chains with the class II binding site replaced by a sequence from influenza virus matrix protein constrain low-affinity sequences to MHC II presentation.Semantic proximity Read ↗

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