Article
Mutations affecting antigen processing impair class II-restricted allorecognition.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1991
Cotner T, Mellins E, Johnson A H, Pious D
Abstract excerpt
Both exogenously derived and endogenously derived Ag generally require processing for their optimal binding and presentation by class I and class II major histocompatibility proteins. It is not known whether steps involved in Ag processing also affect the recognition of alloreactive T cells. We h...
Topics
- Antigen-Presenting Cells
- Antigens
- B-Lymphocytes
- Cell Line
- Clone Cells
- HLA-D Antigens
- HLA-DR3 Antigen
- Humans
- Immunity
- Mutation
- T-Lymphocytes