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Article

Mutations affecting antigen processing impair class II-restricted allorecognition.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1991

Cotner T, Mellins E, Johnson A H, Pious D

Abstract excerpt

Both exogenously derived and endogenously derived Ag generally require processing for their optimal binding and presentation by class I and class II major histocompatibility proteins. It is not known whether steps involved in Ag processing also affect the recognition of alloreactive T cells. We have recently described B cell mutants which have general defects in the processing and presentation of a variety of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 1987270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations affecting antigen processing impair class II-restricted allorecognition.PMID 1987270Read ↗

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes.Semantic proximity Read ↗

Genetics of antigen processing and presentationSemantic proximity Read ↗

Glu227-->Lys substitution in the acidic loop of major histocompatibility complex class I alpha 3 domain distinguishes low avidity CD8 coreceptor and avidity-enhanced CD8 accessory functions.Semantic proximity Read ↗

A mutant antigen-presenting cell defective in antigen presentation expresses class II MHC molecules with an altered conformation.Semantic proximity Read ↗

Mutations in the alpha 1 domain of a class I gene define residues important for specific allorecognition.Semantic proximity Read ↗

Role of ICAM-1 in antigen presentation demonstrated by ICAM-1 defective mutants.Semantic proximity Read ↗

Identification of a Tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen.Semantic proximity Read ↗

Gene required for normal MHC class II expression and function is localized to approximately 45 kb of DNA in the class II region of the MHC.Semantic proximity Read ↗

Presentation of abundant endogenous class II DR-restricted antigens by DM-negative B cell lines.Semantic proximity Read ↗

Point mutations define positions in HLA-DR3 molecules that affect antigen presentation.Semantic proximity Read ↗

Mutant MHC class I molecules define interactions between components of the peptide-loading complex.Semantic proximity Read ↗

A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex.Semantic proximity Read ↗

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