Article
Involvement of p53 gene mutations in human endometrial carcinomas.
International journal of cancer - 1 Apr 1993
Honda T, Kato H, Imamura T, Gima T, Nishida J, Sasaki M, Hoshi K, Sato A, Wake N
Abstract excerpt
Mutations in the p53 gene are associated with a wide variety of human malignancies. Point mutation in one allele and loss of the remaining one generally lead to inactivation of p53 protein. A high frequency of allelic losses corresponding to the 17p13.3 region that contained the p53 gene sequence...
Topics
- Adenocarcinoma
- Alleles
- Base Sequence
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- DNA, Neoplasm
- DNA, Single-Stranded
- Endometrial Neoplasms
- Female
- Genes, p53
- Humans
- Molecular Sequence Data
- Nucleic Acid Conformation
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic