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Article

Copy-neutral loss of heterozygosity at the p53 locus in carcinogenesis of esophageal squamous cell carcinomas associated with p53 mutations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2011

Saeki Hiroshi, Kitao Hiroyuki, Yoshinaga Keiji, Nakanoko Tomonori, Kubo Nobuhide, Kakeji Yoshihiro, Morita Masaru, Maehara Yoshihiko

Abstract excerpt

PURPOSE: LOH at the p53 locus has been reported to be associated with esophageal squamous cell carcinogenesis. The aim of this study is to identify potential mechanisms resulting in LOH around the p53 locus in its carcinogenesis. EXPERIMENTAL DESIGN: We investigated 10 esophageal cancer cell lines and 91 surgically resected specimens, examining them for LOH at the p53 locus on chromosome 17. We examined the p53...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

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Source

Identifiers

PMID: 21325068
DOI: 10.1158/1078-0432.CCR-10-1996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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