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Mutational signatures in T-lymphocytes of rats treated with N-propyl-N-nitrosourea and procarbazine.

Environmental and molecular mutagenesis - 1 Jul 2021

Revollo Javier R, McKinzie Page B, Robison Timothy W, Dobrovolsky Vasily N

Abstract excerpt

We have used whole genome sequencing (WGS) to determine mutational signatures induced in the T-cells of rats treated in vivo with N-propyl-N-nitrosourea (PNU) or procarbazine (PCZ). The signatures from the treated rats were different from the signature of background mutations. The main component of the spontaneous T-cell mutational signature was C➔T transition with all other single base substitutions evenly...

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PMID: 34117657
DOI: 10.1002/em.22448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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