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Article

Mutational specificity of the carcinogen 3-amino-1-methyl-5H-pyrido[4,3-b]-indole in mammalian cells.

Carcinogenesis - 1 May 1990

Akagi T, Morota K, Iyehara-Ogawa H, Kimura H, Kato T

Abstract excerpt

We have used the pZipHprtNeo shuttle vector to determine the types of DNA sequence alterations induced by a potent carcinogen 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P2). The shuttle vector contains a human cDNA hprt as the target gene and is stably integrated into a chromosome of the mouse cell line VH12. After Trp-P2 treatment, 59 independent HPRT- mutant clones of VH12 were isolated and altered sequences...

Topics

Animals
Base Sequence
Carbolines
Carcinogens
Cattle
Cells, Cultured
DNA
DNA Damage
Genes
Guanine
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Thioguanine

Thymine

Source

Identifiers

PMID: 2335011
DOI: 10.1093/carcin/11.5.841

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2335011-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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