P53 as a marker of the malignant cell in Hodgkin's disease.

doi:10.1093/annonc/5.suppl_1.s89

Back to search

Article

P53 as a marker of the malignant cell in Hodgkin's disease.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 1994

Pasman P C, Tiebosch A, Erdkamp F L, Vrints L W, Breed W P, Schouten H C

Abstract excerpt

BACKGROUND: The p53 gene has a tumor-suppressor function. The mutated gene encodes for a protein which has a longer half-life than the normal p53 protein. This enables the detection of the mutated p53 protein by immunohistochemistry. MATERIALS AND METHODS: In this study we examined 53 lymph nodes...

Topics

Genes, p53
Genetic Markers
Hodgkin Disease
Humans
Immunoenzyme Techniques
Mutation
Tumor Suppressor Protein p53

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.