Article
p53 mutations in Hodgkin's disease.
Laboratory investigation; a journal of technical methods and pathology - 1 Oct 1996
Chen W G, Chen Y Y, Kamel O W, Koo C H, Weiss L M
Abstract excerpt
Although numerous studies have demonstrated increased expression of p53 protein in the Reed-Sternberg cells of Hodgkin's disease, little data exist as to whether mutations of the p53 gene is a common occurrence in this neoplasm. Using a microdissection technique coupled with PCR, single-strand conformation analysis, and DNA sequencing, we studied 23 cases of Hodgkin's disease for mutations within exons 5 to 8 of...
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