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Article

Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease.

Blood - 1 Sept 1999

Montesinos-Rongen M, Roers A, Küppers R, Rajewsky K, Hansmann M L

Abstract excerpt

Point mutations of the p53 tumor suppressor gene are a frequent finding in human carcinomas and are thought to be an important oncogenic event. In non-Hodgkin lymphomas, p53 mutations occur in a minor fraction of cases. However, conclusive data are still lacking for Hodgkin's disease (HD) where the analysis meets technical problems. The neoplastic tumor cell clone in HD is represented by the large Hodgkin and...

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PMID: 10477701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease.PMID 10477701Read ↗

Mutation of p53 in primary biopsy material and cell lines from Hodgkin disease.Semantic proximity Read ↗

p53 mutations in Hodgkin's disease.Semantic proximity Read ↗

TP53 gene mutations in Hodgkin lymphoma are infrequent and not associated with absence of Epstein-Barr virus.Semantic proximity Read ↗

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Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.Semantic proximity Read ↗

Hodgkin and Reed–Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cellsSemantic proximity Read ↗

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.Semantic proximity Read ↗

P53 expression in Reed-Sternberg cells does not correlate with gene mutations in Hodgkin's disease.Semantic proximity Read ↗

N-ras genes are not mutated in Hodgkin and Reed-Sternberg cells: results from single cell polymerase chain-reaction examinations.Semantic proximity Read ↗

Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.Semantic proximity Read ↗

p53 protein expression in non-Hodgkin's lymphomas is infrequently related to p53 gene mutations.Semantic proximity Read ↗

The expression of p53 protein in non-Hodgkin's lymphomas is not always dependent on p53 gene mutations.Semantic proximity Read ↗

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