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Article

THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.

American journal of human genetics - 1 Apr 1993

Bowcock A M, Anderson L A, Friedman L S, Black D M, Osborne-Lawrence S, Rowell S E, Hall J M, Solomon E, King M C

Abstract excerpt

In order to pinpoint the locale of the gene for early-onset familial breast and ovarian cancer (BRCA1), polymorphisms were developed within the locus for thyroid hormone receptor alpha (THRA1) and for several anonymous sequences at chromosome 17q12-q21. The THRA1 polymorphism is a dinucleotide repeat with 10 alleles and heterozygosity.79. Gene mapping in extended families with inherited, early-onset breast and...

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Source

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Identifiers

PMID: 8460637
PMCID: PMC1682071

Genes

BRCA1
NGFR
NME1
NME2
RARA
WNT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.PMID 8460637Read ↗

Genetic mapping of the breast-ovarian cancer syndrome to a small interval on chromosome 17q12-21: exclusion of candidate genes EDH17B2 and RARA.Semantic proximity Read ↗

High-density genetic map of the BRCA1 region of chromosome 17q12-q21.Semantic proximity Read ↗

Characterization of 10 new polymorphic dinucleotide repeats and generation of a high-density microsatellite-based physical map of the BRCA1 region of chromosome 17q21.Semantic proximity Read ↗

Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.Semantic proximity Read ↗

Localisation of the breast-ovarian cancer susceptibility gene (BRCA1) on 17q12-21 to an interval of < or = 1 cM.Semantic proximity Read ↗

Genetic mapping of the BRCA1 region on chromosome 17q21.Semantic proximity Read ↗

A breast-ovarian cancer susceptibility gene maps to chromosome 17q21.Semantic proximity Read ↗

Physical mapping, cloning, and identification of genes within a 500-kb region containing BRCA1.Semantic proximity Read ↗

CGH analysis of familial non-BRCA1/BRCA2 breast tumors and mutation screening of a candidate locus on chromosome 17q11.2-12.Semantic proximity Read ↗

A radiation hybrid map of the BRCA1 region.Semantic proximity Read ↗

Assignment of an autosomal sex reversal locus (SRA1) and campomelic dysplasia (CMPD1) to 17q24.3-q25.1.Semantic proximity Read ↗

Genetic analysis of the BRCA1 region in a large breast/ovarian family: refinement of the minimal region containing BRCA1.Semantic proximity Read ↗

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