THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.

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Article

THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.

American journal of human genetics - 1 Apr 1993

Bowcock A M, Anderson L A, Friedman L S, Black D M, Osborne-Lawrence S, Rowell S E, Hall J M, Solomon E, King M C

Abstract excerpt

In order to pinpoint the locale of the gene for early-onset familial breast and ovarian cancer (BRCA1), polymorphisms were developed within the locus for thyroid hormone receptor alpha (THRA1) and for several anonymous sequences at chromosome 17q12-q21. The THRA1 polymorphism is a dinucleotide re...

Topics

Adult
Alleles
Base Sequence
Breast Neoplasms
Chromosome Mapping
Chromosomes, Human, Pair 17
DNA, Neoplasm
Family Health
Female
Genetic Linkage
Genetic Markers
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Neoplastic Syndromes, Hereditary

Oligonucleotide Probes

Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 8460637
PMCID: PMC1682071

Genes

BRCA1
NGFR
NME1
NME2
RARA
WNT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8460637-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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