Article
Genetic mapping of the breast-ovarian cancer syndrome to a small interval on chromosome 17q12-21: exclusion of candidate genes EDH17B2 and RARA.
Human molecular genetics - 1 Aug 1993
Simard J, Feunteun J, Lenoir G, Tonin P, Normand T, Luu The V, Vivier A, Lasko D, Morgan K, Rouleau G A
Abstract excerpt
A susceptibility gene for hereditary breast-ovarian cancer, BRCA1, has been assigned by linkage analysis to chromosome 17q21. Candidate genes in this region include EDH17B2, which encodes estradiol 17 beta-hydroxysteroid dehydrogenase II (17 beta-HSD II), and RARA, the gene for retinoic acid rece...
Topics
- 17-Hydroxysteroid Dehydrogenases
- Base Sequence
- Breast Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- DNA Primers
- DNA, Neoplasm
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Humans
- Male
- Molecular Sequence Data
- Ovarian Neoplasms