Article
Genetic analysis of the BRCA1 region in a large breast/ovarian family: refinement of the minimal region containing BRCA1.
Human molecular genetics - 1 Nov 1993
Kelsell D P, Black D M, Bishop D T, Spurr N K
Abstract excerpt
We have analyzed a single multi-affected breast/ovarian cancer pedigree (BOV3) and have shown consistent inheritance of markers on chromosome 17q with the disease confirming that this family is due to the BRCA1 gene. Analysis of 17q haplotypes shows a recombination event in a bilateral breast can...
Topics
- Alleles
- Base Sequence
- Breast Neoplasms
- Chromosome Aberrations
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- DNA Primers
- DNA, Neoplasm
- DNA, Satellite
- Estradiol Dehydrogenases
- Female
- Genes, Tumor Suppressor
- Genetic Markers
- Humans
- Male
- Molecular Sequence Data
- Ovarian Neoplasms
- Pedigree