Article
Localisation of the breast-ovarian cancer susceptibility gene (BRCA1) on 17q12-21 to an interval of < or = 1 cM.
Genes, chromosomes & cancer - 1 May 1994
Smith S A, DiCioccio R A, Struewing J P, Easton D F, Gallion H H, Albertsen H, Mazoyer S, Johansson B, Steichen-Gersdorf E, Stratton M
Abstract excerpt
A breast-ovarian cancer susceptibility gene, BRCA1, which is responsible for disease in approximately 45% of breast cancer families and most families that contain breast and ovarian cancer, has been assigned by genetic linkage to 17q12-21. Here, we report the analysis of three marker-disease recombinants in families that contain breast and ovarian cancer, two of which strongly suggest a location for BRCA1...
Topics
- Adult
- Base Sequence
- Breast Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- DNA Primers
- DNA, Satellite
- Estradiol Dehydrogenases
- Female
- Genetic Predisposition to Disease