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Article

Direct growth stimulation of normal human epithelial cells by mutant p53.

Molecular carcinogenesis - 1 Jan 1993

Wyllie F S, Lemoine N R, Barton C M, Dawson T, Bond J, Wynford-Thomas D

Abstract excerpt

We developed a high-titer amphotropic retroviral vector that expresses mutant (Ala143) human p53 to test directly the response of genetically normal human epithelial cells to p53 mutation. Contrary to our prediction, we found that in pancreatic epithelium (whose tumors display a high frequency of p53 mutation) but not in thyroid (whose tumors show an exceptionally low mutation frequency), expression of mutant p53...

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Source

Identifiers

PMID: 8457292
DOI: 10.1002/mc.2940070205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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