Direct growth stimulation of normal human epithelial cells by mutant p53.

doi:10.1002/mc.2940070205

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Article

Direct growth stimulation of normal human epithelial cells by mutant p53.

Molecular carcinogenesis - 1 Jan 1993

Wyllie F S, Lemoine N R, Barton C M, Dawson T, Bond J, Wynford-Thomas D

Abstract excerpt

We developed a high-titer amphotropic retroviral vector that expresses mutant (Ala143) human p53 to test directly the response of genetically normal human epithelial cells to p53 mutation. Contrary to our prediction, we found that in pancreatic epithelium (whose tumors display a high frequency of...

Topics

Cell Division
Cell Transformation, Neoplastic
Epithelial Cells
Epithelium
Gene Expression Regulation, Neoplastic
Genes, p53
Genetic Vectors
Humans
Mutation
Pancreatic Neoplasms
Retroviridae
Thyroid Neoplasms
Tumor Suppressor Protein p53

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