Article
Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles.
Anticancer research - 1 Jan 2000
Runnebaum I B, Yee J K, Kieback D G, Sukumar S, Friedmann T
Abstract excerpt
We have examined the effect of expression of a retrovirally mediated wild-type (wt) p53 allele on the neoplastic properties of five human breast cancer cell lines expressing mutant p53. After infection with the retroviral vector Lhp53RNL expressing both the neomycin phosphotransferase gene and the wt p53 gene, the ability of infected cells to form colonies in G418 selective medium was markedly reduced and their...
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