Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles.

Article

Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles.

Anticancer research - 1 Jan 2000

Runnebaum I B, Yee J K, Kieback D G, Sukumar S, Friedmann T

Abstract excerpt

We have examined the effect of expression of a retrovirally mediated wild-type (wt) p53 allele on the neoplastic properties of five human breast cancer cell lines expressing mutant p53. After infection with the retroviral vector Lhp53RNL expressing both the neomycin phosphotransferase gene and th...

Topics

Alleles
Base Sequence
Breast Neoplasms
Cell Division
Female
Genes, p53
Humans
Molecular Sequence Data
Mutation
Phenotype
Polymerase Chain Reaction
Tumor Cells, Cultured

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