Article
Escape from senescence in human diploid fibroblasts induced directly by mutant p53.
Oncogene - 1 Jul 1994
Bond J A, Wyllie F S, Wynford-Thomas D
Abstract excerpt
Cellular senescence is thought to be a key restraint on the progression of human tumours, escape from which involves loss of function of tumour suppressor genes. The number and nature of the genes involved however is uncertain, in particular the role of p53 mutation, which is commonly correlated with tumour progression. To address this question, we used the novel approach of directly assessing the effect of...
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