Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

Article

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

Oncogene - 1 Jul 1994

Bond J A, Wyllie F S, Wynford-Thomas D

Abstract excerpt

Cellular senescence is thought to be a key restraint on the progression of human tumours, escape from which involves loss of function of tumour suppressor genes. The number and nature of the genes involved however is uncertain, in particular the role of p53 mutation, which is commonly correlated...

Topics

Cells, Cultured
Cellular Senescence
Diploidy
Fibroblasts
Genes, p53
Genetic Vectors
Humans
Mutation
Retroviridae
Transfection

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