Article
Mutational specificity of 2-nitro-3,4-dimethylimidazo[4,5-f]quinoline in the lacI gene of Escherichia coli.
Carcinogenesis - 1 Mar 1993
Kosakarn P, Halliday J A, Glickman B W, Josephy P D
Abstract excerpt
2-Nitro-3,4-dimethylimidazo[4,5-f]quinoline (NO2-MeIQ) is the nitro derivative of 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), one of the food pyrolysis product mutagens and carcinogens. The mutational specificity of NO2-MeIQ was determined using the lacI system in an Escherichia coli stra...
Topics
- Bacterial Proteins
- Base Composition
- Base Sequence
- Dose-Response Relationship, Drug
- Escherichia coli
- Escherichia coli Proteins
- Lac Operon
- Lac Repressors
- Molecular Sequence Data
- Mutagens
- Mutation
- Nitroimidazoles
- Quinolines
- Repressor Proteins