Article
Analysis of mutational specificity induced by heterocyclic amines in the lacZ gene of Escherichia coli.
Carcinogenesis - 1 Jun 1993
Watanabe M, Ohta T
Abstract excerpt
Mutational spectra induced by different heterocyclic amines were characterized and compared with those obtained from diethylnitrosamine and N-methyl-N-nitrosourea. Mutation classes were identified by means of a series of mutant lacZ genes in F' episomes in Escherichia coli engineered to detect specifically each of two transitions, four transversions and five kinds of frameshift events. More than 99.5% of the...
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