Mutational specificity of 2-amino-3-methylimidazo-[4,5-f]quinoline in the hprt locus of CHO-K1 cells.

doi:10.1002/mc.2940130209

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Article

Mutational specificity of 2-amino-3-methylimidazo-[4,5-f]quinoline in the hprt locus of CHO-K1 cells.

Molecular carcinogenesis - 1 Jun 1995

Lee H, Shih M K

Abstract excerpt

2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), a food carcinogen formed in cooked meats, can induce gene mutation at the hprt locus of CHO-K1 cells in the presence of hepatic S9 mix. To elucidate the molecular nature of IQ-induced mutation, we characterized the entire coding region of the hypoxant...

Topics

Animals
Base Sequence
CHO Cells
Cricetinae
DNA, Complementary
Exons
Gene Amplification
Gene Deletion
Hypoxanthine Phosphoribosyltransferase
Kinetics
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutagens
Mutation
Polymerase Chain Reaction
Quinolines

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