Article
Molecular analysis of mutations induced by ethylating N-nitroso compounds in the lacI gene of Escherichia coli.
Mutation research - 10 Jun 1996
Jiao J, Pienkowska M, Glickman B W, Zielenska M
Abstract excerpt
We have investigated the mutational specificities of two ethylating agents, N-nitroso-N,N-diethylamine (NDEA) and N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) in the NC+ domain of the lacI gene in Escherichia coli. G:C-->A:T transitions predominated in each of the two spectra, but its importance varies. While 95% of mutations induced by ENNG are G:C-->A:T transition, they account for only 61% of the total events...
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