Fpg protein protects Escherichia coli K-12 from mutation induction by the carcinogen 4-nitroquinoline 1-oxide.

doi:10.1093/carcin/15.3.425

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Article

Fpg protein protects Escherichia coli K-12 from mutation induction by the carcinogen 4-nitroquinoline 1-oxide.

Carcinogenesis - 1 Mar 1994

Ruiz-Laguna J, Ariza R R, Prieto-Alamo M J, Boiteux S, Pueyo C

Abstract excerpt

This paper investigates the role of the fpg gene product in protecting Escherichia coli cells against the lethal and mutagenic effects of 4-nitroquinoline 1-oxide (4NQO). To this end, the araD81 mutation which make the cells sensitive to L-arabinose was combined with an fpg-1::Knr allele, in eith...

Topics

4-Nitroquinoline-1-oxide
Arabinose
Drug Resistance
Escherichia coli
Mutagenicity Tests
Mutation
N-Glycosyl Hydrolases
Phenotype
Plasmids

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