Article
Prognostic significance of TP53 alterations in breast carcinoma.
British journal of cancer - 1 Sept 1993
Andersen T I, Holm R, Nesland J M, Heimdal K R, Ottestad L, Børresen A L
Abstract excerpt
Constant denaturant gel electrophoresis (CDGE) was used to screen 179 breast carcinomas for mutations in the conserved regions of the TP53 gene (exons 5 through 8). Mutations were found in 35 of 163 primary tumours (21%) and in 5 of 16 metastases (31%) and resided predominantly in exon 7. The maj...
Topics
- Adult
- Aged
- Breast Neoplasms
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Middle Aged
- Multivariate Analysis
- Mutation
- Oncogene Proteins, Viral
- Prognosis
- Receptor, ErbB-2
- Receptors, Estrogen
- Receptors, Progesterone
- Time Factors
- Tumor Suppressor Protein p53