TP53 mutation patterns in breast cancers: searching for clues of environmental carcinogenesis.

Abstract excerpt

Mutations in the tumour suppressor gene TP53 occur in about 30% of breast cancers. We have used the IARC TP53 mutation database to analyse the pattern of mutations in breast cancers (1392 mutations). The global pattern of mutations is similar to the one of most other cancers, but there is an excess of transversions on G bases in tumours from Western (USA and Europe) as compared to Eastern (Japan) countries....

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