The molecular epidemiology of p53 gene mutations in human breast cancer.

doi:10.1016/s0168-9525(96)10043-3

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Article

The molecular epidemiology of p53 gene mutations in human breast cancer.

Trends in genetics : TIG - 1 Jan 1997

Hartmann A, Blaszyk H, Kovach J S, Sommer S S

Abstract excerpt

The P53 tumor-suppressor gene is an advantageous tool for analyzing the molecular epidemiology of cancer. We describe the utility of the P53 gene as a 'mutagen test' and a prognostic indicator in breast cancer. Aspects of study design and methodology are discussed. Two major conclusions emerge: (...

Topics

Breast Neoplasms
Female
Genes, p53
Humans
Japan
Mutagens
Mutation
Predictive Value of Tests
Prognosis
Tumor Suppressor Protein p53

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