Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.

doi:10.1101/gad.7.3.454

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Article

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.

Genes & development - 1 Mar 1993

Miller M W, Duhl D M, Vrieling H, Cordes S P, Ollmann M M, Winkes B M, Barsh G S

Abstract excerpt

The mouse agouti gene controls the deposition of yellow and black pigment in developing hairs. Several dominant alleles, including lethal yellow (Ay), result in the exclusive production of yellow pigment and have pleiotropic effects that include obesity and increased tumor susceptibility. In an i...

Topics

Agouti Signaling Protein
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Cosmids
Crosses, Genetic
DNA
Embryo, Mammalian
Female
Genes, Lethal
Hair Color
In Situ Hybridization
Intercellular Signaling Peptides and Proteins
Male
Mice
Mice, Mutant Strains
Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 8449404
DOI: 10.1101/gad.7.3.454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8449404-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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