Article
Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts.
Genes & development - 15 Feb 1994
Bultman S J, Klebig M L, Michaud E J, Sweet H O, Davisson M T, Woychik R P
Abstract excerpt
The agouti gene regulates the differential production of eumelanin (black or brown) and phaeomelanin (yellow) pigment granules by melanocytes in the hair follicles of mice. The original nonagouti (a) allele, which confers a predominantly black coat color, has been shown to revert to two other mor...
Topics
- Alleles
- Animals
- Base Sequence
- DNA
- DNA Mutational Analysis
- Gene Rearrangement
- Melanins
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Recombination, Genetic
- Repetitive Sequences, Nucleic Acid