Article
Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 1994
Yen T T, Gill A M, Frigeri L G, Barsh G S, Wolff G L
Abstract excerpt
The viable yellow A(vy) mutation results in a mottled yellow mouse that is obese, slightly larger than its nonyellow sibs, and more susceptible to tumor formation in those tissues sensitized by the strain genome. The mutation exhibits variable expressivity resulting in a continuum of coat color phenotypes, from clear yellow to pseudoagouti. The mouse agouti protein is a paracrine signaling molecule that induces...
Topics
- Agouti Signaling Protein
- Amino Acid Sequence
- Animals
- Diabetes Mellitus
- Gene Expression
- Intercellular Signaling Peptides and Proteins
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Molecular Sequence Data