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Article

The molecular basis for dominant yellow agouti coat color mutations.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Oct 1994

Perry W L, Copeland N G, Jenkins N A

Abstract excerpt

Agouti expression during the middle portion of the mouse hair growth cycle induces melanocytes to synthesize yellow instead of black pigment, generating black hairs with a yellow band. Dominant agouti alleles increase the amount of yellow pigment in the coat and are associated with pleiotropic effects including obesity, diabetes and increased tumor susceptibility. Four dominant agouti alleles (Aiapy, Aiy, and...

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Identifiers

PMID: 7980472
DOI: 10.1002/bies.950161002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The molecular basis for dominant yellow agouti coat color mutations.PMID 7980472Read ↗

Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage.Semantic proximity Read ↗

Neomorphic agouti mutations in obese yellow mice.Semantic proximity Read ↗

The agouti gene: turned on to yellow.Semantic proximity Read ↗

Molecular characterization of the mouse agouti locus.Semantic proximity Read ↗

Hypervariable yellow (Ahvy), a new murine agouti mutation: Ahvy displays the largest variation in coat color phenotypes of all known agouti alleles.Semantic proximity Read ↗

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.Semantic proximity Read ↗

Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts.Semantic proximity Read ↗

Overexpression of an Agouti cDNA in the skin of transgenic mice recapitulates dominant coat color phenotypes of spontaneous mutants.Semantic proximity Read ↗

Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene.Semantic proximity Read ↗

Epigenetic inheritance at the agouti locus in the mouse.Semantic proximity Read ↗

Molecular basis of the pleiotropic phenotype of mice carrying the hypervariable yellow (Ahvy) mutation at the agouti locus.Semantic proximity Read ↗

The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenomeSemantic proximity Read ↗

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